Results from novel imaging analysis of the Endogenous Tissue Restoration (ETR) process in Xeltis’ devices further advance the understanding of in vivo polymer absorption and neotissue formation. The outcomes have been obtained using a novel, non-invasive, laser-based imaging method and have been published in peer-reviewed, open source journal Frontiers in Cardiovascular Medicine.
According to the Frontier paper, the data analysis allowed to trace the restoration and absorption processes in vitro and in vivo and to compare them. The data indicated similar molecular observations and, interestingly, provided information on collagen deposition and composition simultaneously from the same image scans.
“Unraveling the mechanisms of polymer degradation at molecular level and correlating in vitro and in vivo processes is highly relevant for the design of successful implants requiring long-term functionality, biocompatibility and immunocompatibility,” explained Martijn Cox, Xeltis CTO and Co-Founder. “These observations further enhance our understanding of ETR and potentially lead the way to accelerate our future learnings”.
The Raman spectroscopy is a relatively new imaging method in the field of biological tissues. It is of great interest for both in vitro and in vivo applications, due to its non-invasive nature and ease of sample preparation compared to more conventional methods.
Read the full Frontiers paper here