Xeltis’ solution: Xeltis restorative CABG offers a true alternative to vein harvesting. It enables the body to develop a new blood vessel to potentially reduce complications and overall healthcare costs.
Patients: Around 1 million patients undergo CABG surgery each year.
Current standard of care: CABG surgery is the gold standard for coronary artery disease treatment caused by multiple blood vessel occlusion/narrowing.1,2,3,4,5,6
It is normally performed by harvesting patient’s own veins,7 an additional surgery that may lead to pain and infections.8,9 Synthetic grafts are currently not available.
Current limitations: On average, around 20 percent of veins occlude by the end of the first year after CABG surgery.6
 Benjamin EJ, et al. Heart Disease and Stroke Statistics-2018 Update: A Report From the American Heart Association. Circulation. 2018 Mar 20;137(12):e67-e492
 Benedetto U, et al. Coronary surgery is superior to drug eluting stents in multivessel disease. Systematic review and meta-analysis of contemporary randomized controlled trials. Int J Cardiol 2016;210:19–24.
 Mohr FW, et al. Coronary artery bypass graft surgery versus percutaneous coronary intervention in patients with three-vessel disease and left main coronary disease: 5-year follow-up of the randomised, clinical SYNTAX trial. Lancet 2013 Feb 23;381(9867):629-38
 Mäkikallio T, et al. Percutaneous coronary angioplasty versus coronary artery bypass grafting n treatment of unprotected left main stenosis (NOBLE), a prospective , randomised, open label, non inferiority trial. Lancet 2016, October 31. S0140-6736(16)32052-9
 Taggart DP, et al, A prospective study of external stenting of saphenous vein grafts to the right coronary artery: the VEST II study. European Journal of Cardio-Thoracic Surgery 0 (2017) 1–7
 Shavadia J. Symptomatic graft failure and impact on clinical outcome after coronary artery bypass grafting surgery: Results from the Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease registry. Am Heart J. 2015 Jun;169(6):833-40.
 Tabata M, et al. Prevalence and variability of internal mammary artery graft use in contemporary multivessel coronary artery bypass graft surgery: analysis of the society of thoracic surgeons national cardiac database. Circulation, 2009;120:935–40.
. Crouch, J. D. et al. Open versus endoscopic saphenous vein harvesting: Wound complications and vein quality. in Annals of Thoracic Surgery (1999). doi:10.1016/S0003-4975(99)00947-9
. Allen, K. B. et al. Influence of endoscopic versus traditional saphenectomy on event-free survival: five-year follow-up of a prospective randomized trial. Heart Surg Forum (2003). doi:10.1532/hsf.1020